2-Methoxyaniline → Acetamide, N-(2-methoxyphenyl)-

HRID 1648957

Reaktionsgleichung

Reaktionsgleichung von HRID 1648957
[CH3:1][O:2][C:3]1[C:4]([NH2:9])=[CH:5][CH:6]=[CH:7][CH:8]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>>[CH3:11][C:10]([NH:9][C:4]1[C:3]([O:2][CH3:1])=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:12]

Komponenten

3

Edukt 2

HCID 70002-MethoxyanilineHCID 7918Acetic Anhydride

Produkt 1

HCID 7135Acetamide, N-(2-methoxyphenyl)-

Reaktionsbedingungen

Temperatur
45 °C

Versuchsvorschrift

To 100 ml of acetic anhydride was added dropwise with stirring 100 g (0.813 mole) of o-anisidine, the temperature rising to about 60° C. during addition. The reaction mixture was heated on a steam bath for 15 minutes, allowed to cool to 45° C. and was poured onto 500 g of crushed ice. The white solid that precipitated was collected, washed free of acid with water and air dried to give 100 g, m.p. 84°-86° C., of product.

Aufarbeitung

  1. additionthe temperature rising to about 60° C. during addition
  2. temperatureThe reaction mixture was heated on a steam bath for 15 minutes
  3. customThe white solid that precipitated
  4. customwas collected
  5. washwashed free of acid with water and air
  6. customdried
  7. customto give 100 g, m.p. 84°-86° C.

Quellen und Nachweise

ORD-Eintrag
ord-dd72855b9a824be39a73e3a9415ab444
Quelldatensatz
uspto-grants-1983_11
Patentnummer
US04414320

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