Formic Acid → (1-Aminoethylidene)bisphosphonic acid

Reaktionsgleichung

[C:1]([O-])(=O)[CH3:2].[NH4+:5].C(O)=O.O1P2[O:15][P:16]3[O:18]P(O2)OP1[O:17]3>>[NH2:5][C:1]([P:16]([OH:15])(=[O:17])[OH:18])([P:16]([OH:18])(=[O:15])[OH:17])[CH3:2]

Komponenten

Edukt 3

HCID 284Formic Acid

HCID 1232902,4,6,8,9,10-Hexaoxa-1,3,5,7-tetraphosphatricyclo(3.3.1.13,7)decane

HCID 517165Ammonium Acetate

Produkt 1

HCID 84770(1-Aminoethylidene)bisphosphonic acidAusbeute 175,6 %

Versuchsvorschrift

The procedure was as described in Example 1, but a blend of 40.5 g (0.525 mol) ammonium acetate and 23 g (0.5 mol) formic acid was reacted with 55 g (0.25 mol) P4O6. 45 g 1-aminoethane-1,1-diphosphonic acid was obtained.

Quellen und Nachweise

ORD-Eintrag: ord-d6c6ef98f394482981ba5755adf272f0
Quelldatensatz: uspto-grants-1983_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04418019

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