StartseiteMCPWorkbenchSkills
StartseiteWorkbenchBenachrichtigungenMein Bereich
llms.txt · MCP-AnleitungDatenschutz · Nutzungsbedingungen · Supportv1.8.0
  1. Startseite
  2. /Reaktion

Raloxifene → 6-Acetoxy-2-(4-acetoxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene

HRID 1649613
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1649613
[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:9]([C:10](=[O:26])[C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]4[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]4)=[CH:13][CH:12]=3)=[C:8]([C:27]3[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=3)[S:7][C:6]=2[CH:34]=1.[O:35]1[CH2:39][CH2:38]CC1.C(=O)([O-])[O-].[K+].[K+].[C:46](OC(=O)C)(=[O:48])[CH3:47]>C(Cl)(Cl)Cl>[C:46]([O:1][C:2]1[CH:3]=[CH:4][C:5]2[C:9]([C:10](=[O:26])[C:11]3[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][N:20]4[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]4)=[CH:15][CH:16]=3)=[C:8]([C:27]3[CH:28]=[CH:29][C:30]([O:33][C:39](=[O:35])[CH3:38])=[CH:31][CH:32]=3)[S:7][C:6]=2[CH:34]=1)(=[O:48])[CH3:47]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 5035RaloxifeneHCID 7918Acetic AnhydrideHCID 8028TetrahydrofuranHCID 11430Potassium Carbonate

Produkt 1

HCID 109952786-Acetoxy-2-(4-acetoxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212
Chloroform
Lösungsmittel

Versuchsvorschrift

Two g. of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene was dissolved in 30 ml. of tetrahydrofuran, and 3.5 g. of potassium carbonate was added. The vessel was blanketed with nitrogen and 0.9 g. of acetic anhydride was added. The mixture was stirred at ambient temperature for 2 hours, and then under reflux for 2 hours more. The mixture was then cooled, and to it was added 200 ml. of chloroform. The mixture was washed with 100 ml. of aqueous sodium chloride solution, and the organic layer was dried over magnesium sulfate, filtered and evaporated to dryness under vacuum at 40° C. A white foam was obtained, which was determined to be the desired product.

Aufarbeitung

  1. temperatureunder reflux for 2 hours more
  2. temperatureThe mixture was then cooled
  3. additionto it was added 200 ml
  4. washThe mixture was washed with 100 ml
  5. dry with materialof aqueous sodium chloride solution, and the organic layer was dried over magnesium sulfate
  6. filtrationfiltered
  7. customevaporated to dryness under vacuum at 40° C
  8. customA white foam was obtained

Quellen und Nachweise

ORD-Eintrag
ord-fe882985eef640c38a91539ddaec3a9f
Quelldatensatz
uspto-grants-1983_11
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US04418068

Notizen zur Reaktion

Wird geladen…

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion