Hydrochloric Acid → 2-(4-(3,5-Dichlorophenylureido)phenoxy)-2-methylpropionic acid

HRID 1649934

Reaktionsgleichung

Reaktionsgleichung von HRID 1649934
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:17]=[C:18]([N:23]=[C:24]=[O:25])[CH:19]=[C:20]([Cl:22])[CH:21]=1.O.Cl>N1C=CC=CC=1>[Cl:15][C:16]1[CH:17]=[C:18]([NH:23][C:24](=[O:25])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([OH:10])=[O:9])=[CH:13][CH:14]=2)[CH:19]=[C:20]([Cl:22])[CH:21]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 944603,5-Dichlorophenyl isocyanateHCID 27749582-(4-Aminophenoxy)-2-methylpropanoic acid

Produkt 1

HCID 1953472-(4-(3,5-Dichlorophenylureido)phenoxy)-2-methylpropionic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a stirring solution of 4.95 g (0.025 mole) of 2-(4-aminophenoxy)-2-methylpropionic acid in 50 ml dry pyridine, 4.95 g (0.025 mole) of 3,5-dichlorophenyl isocyanate were added. After 1 hour stirring at room temperature, 150 ml water was added and the mixture was acidified with concentrated HCl. The precipitate was filtered, washed several times with cold water and dried. Recrystallization from aqueous acetone gave small plates 1.81 g (94%) MP 182-184°.

Aufarbeitung

  1. filtrationThe precipitate was filtered
  2. washwashed several times with cold water
  3. customdried
  4. customRecrystallization from aqueous acetone
  5. customgave small plates 1.81 g (94%) MP 182-184°

Quellen und Nachweise

ORD-Eintrag
ord-388dc580be304e51a9ccab51f3795d39
Quelldatensatz
uspto-grants-1990_05
Patentnummer
US04921997

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