[NH2:1][C:2]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[C:3]([CH3:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5].N1C=CC=CC=1.[C:22](Cl)(=[O:24])[CH3:23].Cl>O1CCCC1.O>[C:22]([NH:1][C:2]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)=[C:3]([CH3:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5])(=[O:24])[CH3:23]
76 g of ethyl 3-amino-2-methyl-3-phenyl-2-propenoate were maintained at 15° C. in 600 ml of tetrahydrofuran and 32.3 ml of pyridine while adding 28.44 ml of acetyl chloride in 100 ml of tetrahydrofuran. The mixture was refluxed for 1 hour, then cooled and poured into a liter of water acidified to pH 1 with 2N hydrochloric acid. After extracting with ether, washing with water, with a saturated solution of sodium bicarbonate and then with water, drying and concentrating to dryness under reduced pressure, 80 g of the expected product were obtained.
Wird geladen…
