Mercaptoethanesulfonic acid → Mafosfamide Sodium Salt

HRID 1651521

Reaktionsgleichung

Reaktionsgleichung von HRID 1651521
[CH2:1]1[CH:7](O)[NH:6][P:4]([N:9]([CH2:13][CH2:14][Cl:15])[CH2:10][CH2:11][Cl:12])(=[O:5])[O:3][CH2:2]1.[SH:16][CH2:17][CH2:18][S:19]([OH:22])(=[O:21])=[O:20]>O>[Cl:12][CH2:11][CH2:10][N:9]([CH2:13][CH2:14][Cl:15])[P:4]1(=[O:5])[NH:6][CH:7]([S:16][CH2:17][CH2:18][S:19]([OH:22])(=[O:21])=[O:20])[CH2:1][CH2:2][O:3]1

Komponenten

4

Edukt 2

HCID 598Mercaptoethanesulfonic acidHCID 997354-Hydroxycyclophosphamide

Produkt 1

HCID 104746Mafosfamide Sodium Salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

0.8 g (3.0 mmol) of 4-hydroxycyclophosphamide in 3 ml of water were mixed with 420 mg (3.0 mmol) of 2-mercaptoethanesulphonic acid, with ice water cooling. After 1 hour, the mixture was concentrated under high vacuum and was crystallised.

Aufarbeitung

  1. concentrationthe mixture was concentrated under high vacuum
  2. customwas crystallised

Quellen und Nachweise

ORD-Eintrag
ord-fad097d817ef420dbcf6f613fdcfc0b9
Quelldatensatz
uspto-grants-1990_05
Patentnummer
US04929607

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