Piperidine → HCID 178499397, Verbindung

HRID 1651881Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1651881
C1CCNCC1.COC(=O)CC1CCc2cc(Br)cc3[nH]c(=O)c(=O)n1c23>C1CN2CCN1CC2.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.COCCOC.CS(C)=O.F[P-](F)(F)(F)(F)F.[Cl][Ni][Cl].c1ccc(-c2cccc[c]2[Ir+][c]2ccccc2-c2ccccn2)nc1>COC(=O)CC1CCc2cc(N3CCCCC3)cc3[nH]c(=O)c(=O)n1c23

Komponenten

7

Edukt 2

HCID 8082PiperidineHCID 10066635Methyl 2-(9-bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrido[1,2,3-de]quinoxalin-5-yl)acetate

Produkt 1

HCID 178499397HCID 178499397, VerbindungAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 9237DabcoKatalysatorHCID 15773433Dichloronickel;1,2-dimethoxyethaneKatalysatorHCID 178441140HCID 178441140, VerbindungKatalysatorHCID 679Dimethyl SulfoxideLösungsmittel3×

Reaktionsbedingungen

Temperatur
55 °C

Aufarbeitung

  1. additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
  2. aliquot25 microliter of quenched reaction mixture was taken
  3. additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

Quellen und Nachweise

ORD-Eintrag
ord-f7003ac3e4f846a7bdf25dedd29fb9c9
Quelldatensatz
Nano CN PhotoChemistry Informers Library
Originallink
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