Piperidine → HCID 178470271, Verbindung

Reaktionsgleichung

C1CCNCC1.CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(Br)ccc1-2>C1CN2CCN1CC2.COCCOC.CS(C)=O.O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccccc21.[Cl][Ni][Cl]>CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(N3CCCCC3)ccc1-2

Komponenten

Reaktionsbedingungen

Temperatur: 55 °C

Aufarbeitung

additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
aliquot25 microliter of quenched reaction mixture was taken
additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

Quellen und Nachweise

ORD-Eintrag: ord-809b218efff54917a28b57d2acb7caa8
Quelldatensatz: Nano CN PhotoChemistry Informers Library
DOI: 10.1021/acs.accounts.0c00760
Originallink: Quelle ansehen

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Komponenten

Edukt 2

HCID 8082Piperidine

HCID 10737466Ethyl 8-bromo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate

Produkt 1

HCID 178470271HCID 178470271, VerbindungAusbeute 9,115 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 9237DabcoKatalysator

HCID 16850FluoresceinKatalysator

HCID 15773433Dichloronickel;1,2-dimethoxyethaneKatalysator

HCID 679Dimethyl SulfoxideLösungsmittel3×

Reaktionsbedingungen

Temperatur: 55 °C

Aufarbeitung

additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
aliquot25 microliter of quenched reaction mixture was taken
additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

Quellen und Nachweise

ORD-Eintrag: ord-809b218efff54917a28b57d2acb7caa8
Quelldatensatz: Nano CN PhotoChemistry Informers Library
DOI: 10.1021/acs.accounts.0c00760
Originallink: Quelle ansehen

Notizen zur Reaktion

Wird geladen…