Piperidine → HCID 178500184, Verbindung

Reaktionsgleichung

C1CCNCC1.COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Cl)cc1>C1CN2CCN1CC2.COCCOC.CS(C)=O.O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccccc21.[Cl][Ni][Cl]>COC(=O)C(C)(C)Cc1c(SC(C)(C)C)c2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(N2CCCCC2)cc1

Komponenten

Reaktionsbedingungen

Temperatur: 55 °C

Aufarbeitung

additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
aliquot25 microliter of quenched reaction mixture was taken
additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

Quellen und Nachweise

ORD-Eintrag: ord-a79b4964b0f84a4796899ff6cb079519
Quelldatensatz: Nano CN PhotoChemistry Informers Library
DOI: 10.1021/acs.accounts.0c00760
Originallink: Quelle ansehen

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Komponenten

Edukt 2

HCID 8082Piperidine

HCID 15225389Methyl 3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoate

Produkt 1

HCID 178500184HCID 178500184, VerbindungAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 9237DabcoKatalysator

HCID 16850FluoresceinKatalysator

HCID 15773433Dichloronickel;1,2-dimethoxyethaneKatalysator

HCID 679Dimethyl SulfoxideLösungsmittel3×

Reaktionsbedingungen

Temperatur: 55 °C

Aufarbeitung

additionThe samples was moved from a 1536 well plate into a 384 well plate. The 384 well plate contained 75 microliter of 1% Acetic acid in DMSO solution with 0.003M trimethoxybenzene. The reaction plate was rinsed three times with the same solution to make a total addition volume of ~90 microliters
aliquot25 microliter of quenched reaction mixture was taken
additionTo the 25 microliter aliquot 50 microliter of DMSO was added. If the original reaction concentration was 0.05 M (wrt limiting reagent). This would make a final analytical concentration of 0.36 mM which is in line with typical analytical concentrations from this group.

Quellen und Nachweise

ORD-Eintrag: ord-a79b4964b0f84a4796899ff6cb079519
Quelldatensatz: Nano CN PhotoChemistry Informers Library
DOI: 10.1021/acs.accounts.0c00760
Originallink: Quelle ansehen

Notizen zur Reaktion

Wird geladen…