3-Benzyloxy-pyrid-2-ylsulfonamide → 3-Hydroxypyridine-2-sulfonamide

HRID 1653624Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1653624
C([O:8][C:9]1[C:10]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[C:10]([S:15]([NH2:18])(=[O:17])=[O:16])=[N:11][CH:12]=[CH:13][CH:14]=1

Komponenten

4

Edukt 1

HCID 199579343-Benzyloxy-pyrid-2-ylsulfonamide

Produkt 1

HCID 199579383-Hydroxypyridine-2-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 263.7 g of 3-benzyloxy-pyrid-2-ylsulfonamide in 2.5 l of methanol is hydrogenated with the addition of 26 g of 5% Pd/C catalyst. After 23.8 l of hydrogen have been absorbed, the catalyst is filtered off. After evaporation of the methanol, 3-hydroxypyrid-2-ylsulfonamide remains in the form of a crystalline mass. Melting point 162°-164° C.

Aufarbeitung

  1. customAfter 23.8 l of hydrogen have been absorbed
  2. filtrationthe catalyst is filtered off
  3. customAfter evaporation of the methanol, 3-hydroxypyrid-2-ylsulfonamide

Quellen und Nachweise

ORD-Eintrag
ord-eb95c2fac7874c788366ee6643fedcc4
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05403814

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