Methanol → 2-(4-Fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methoxypyrimidine

HRID 1653877Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1653877
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=3)[C:11](S(C)(=O)=O)=[CH:10][N:9]=2)=[CH:4][CH:3]=1.[CH3:28][O-:29].[Na+].CO>COCCOC>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=3)[C:11]([O:29][CH3:28])=[CH:10][N:9]=2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 148836702-(4-Fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methanesulfonylpyrimidine

Produkt 1

HCID 117253022-(4-Fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methoxypyrimidineAusbeute 85,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80711,2-DimethoxyethaneLösungsmittel

Versuchsvorschrift

2 g of 2-(4-fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methanesulfonylpyrimidine, 0.3 g of sodium methoxide and 20 ml of methanol were added to 120 ml of ethylene glycol dimethyl ether, and the resulting mixture was heated under reflux for 5 hours. The solvent was distilled away under reduced pressure. The residue was washed with water, and then dried to obtain 1.5 g of 2-(4-fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methoxypyrimidine (Compound 18).

Aufarbeitung

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 5 hours
  3. distillationThe solvent was distilled away under reduced pressure
  4. washThe residue was washed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-4535da8b1be34b2ea9d918ca9c537000
Quelldatensatz
uspto-grants-1995_04
Patentnummer
US05403948

Notizen zur Reaktion

Wird geladen…