Hydrazine hydrate (1:1) → 8-(3-Trifluoromethylphenyl)pyrido[2,3-d]pyridazin-5-(6H)-one

Beteiligte Stoffe

Reaktionsschritte

A mixture of 2-(3-trifluoromethylbenzoyl)nicotinic acid (1.5 g) and hydrazine hydrate (0.4 g) in ethanol was heated at the reflux temperature for 5 hours. On cooling and reduction of the volume of solvent by evaporation, a precipitate formed which was collected by filtration, to give the title compound as a white solid, 1.08 g, m.p. 210°-215° C.

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