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Hydrochloric Acid → 2-Methyl-4-(trifluoromethyl)-3-furancarboxylic acid

HRID 1654110
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1654110
[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:12]([F:15])([F:14])[F:13])[C:6]=1[C:7]([O:9]CC)=[O:8].C(O)C.[OH-].[Na+].Cl>O>[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:12]([F:14])([F:13])[F:15])[C:6]=1[C:7]([OH:9])=[O:8]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 120093303-Furancarboxylic acid, 2-methyl-4-(trifluoromethyl)-, ethyl ester

Produkt 1

HCID 218197492-Methyl-4-(trifluoromethyl)-3-furancarboxylic acidAusbeute 90,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

Auf dieser SeiteKomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion
HCID 962
Water
Lösungsmittel

Versuchsvorschrift

18 g of the product of Stage B were refluxed for 2 and a half hours in 42 ml of water and 126 ml of ethanol in the presence of 3.55 g of sodium hydroxide. The mixture was allowed to return to room temperature and 2N hydrochloric acid was added to neutrality. The mixture was partially concentrated and 2N sodium hydroxide solution was added. The mixture was extracted with isopropyl ether and the solvent was evaporated to obtain 14.25 g of the expected product melting at 140° C.

Aufarbeitung

  1. customto return to room temperature
  2. concentrationThe mixture was partially concentrated
  3. addition2N sodium hydroxide solution was added
  4. extractionThe mixture was extracted with isopropyl ether
  5. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-db2556f9bd474c59a44562813949abb7
Quelldatensatz
uspto-grants-1995_04
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US05405865

Notizen zur Reaktion

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