HCID 136387274, Verbindung → N2 (4-methoxyphenyldiphenylmethyl)-9-(1,3-dihydroxy-2-propoxymethyl)guanine

HRID 1655343

Reaktionsgleichung

[N:1]#[N:2].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([NH:24][C:25]2[NH:26][C:27](=[O:47])[C:28]3[N:29]=[CH:30][N:31]([CH2:34][O:35][CH:36]([CH2:42][O:43]C(=O)C)[CH2:37][O:38]C(=O)C)[C:32]=3[N:33]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:7][CH:6]=1>CO.[OH-].[NH4+]>[N:1]#[N:2].[CH3:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([NH:24][C:25]2[NH:26][C:27](=[O:47])[C:28]3[N:29]=[CH:30][N:31]([CH2:34][O:35][CH:36]([CH2:37][OH:38])[CH2:42][OH:43])[C:32]=3[N:33]=2)([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:9][CH:10]=1

Komponenten

Reaktionsbedingungen

Temperatur: 50 °C

Versuchsvorschrift

A solution of 4.0 g of N2 -(4-methoxyphenyldiphenylmethyl)-9-(1,3-diacetoxy-2-propoxymethyl)guanine in 100 ml of methanol plus 20 ml of concentrated ammonium hydroxide was magnetically stirred at 22° C. for 16 hours then at 50° C. for 2.5 hours. An additional 10 ml of ammonium hydroxide were then added and the solution stirred another 2.5 hours at 50° C. Next, the solution was concentrated at reduced pressure and the residual solid recrystallized from methanol:ethyl acetate to give 3.5 g of N2 -(4-methoxyphenyldiphenylmethyl)-9-(1,3-dihydroxy-2-propoxymethyl)guanine, m.p. 148°-151° C.

Aufarbeitung

concentrationNext, the solution was concentrated at reduced pressure
customthe residual solid recrystallized from methanol

Quellen und Nachweise

ORD-Eintrag: ord-93ea799914c7419a9044e2916f1ab5d8
Quelldatensatz: uspto-grants-1993_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05250535

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