Hydrochloric Acid → (CH3)3Coc(O)nhch2C(O)nhch2CH3

HRID 1655363Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1655363
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:13]([NH2:15])[CH3:14].Cl.C1CCC(N=C=NC2CCCCC2)CC1>CN(C=O)C>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]([NH:15][CH2:13][CH3:14])=[O:12])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 6341EthylamineHCID 10868DicyclohexylcarbodiimideHCID 78288N-(tert-butoxycarbonyl)glycine

Produkt 1

HCID 57248348(CH3)3Coc(O)nhch2C(O)nhch2CH3

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

t-butoxycarbonyl- glycine (3 g), ethylamine.HCl (1.39 g), TEA (1.72 g), Hobt (2.3 g) and dry DMF (100 ml) were combined and DCC (3.5 g) was added. The mixture was stirred for three days at room temperature under nitrogen, then filtered and evaporated to dryness. 6 g of material was recovered. This material was subjected to column chromatography eluting with a gradient of ethyl acetate to ethyl acetate/methanol (1:1) providing 4.01 g of (CH3)3COC(O)NHCH2C(O)NHCH2CH3.

Aufarbeitung

  1. filtrationfiltered
  2. customevaporated to dryness
  3. custom6 g of material was recovered
  4. washeluting with a gradient of ethyl acetate to ethyl acetate/methanol (1:1)

Quellen und Nachweise

ORD-Eintrag
ord-dbacc820028841d48310f967d915b9d6
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05250542

Notizen zur Reaktion

Wird geladen…