Nitric Acid → HCID 19792129, Verbindung

HRID 1655465Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1655465
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][C:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[N+:19]([O-])([OH:21])=[O:20]>C(OC(=O)C)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([N+:19]([O-:21])=[O:20])[C:5]([NH:12][C:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

Komponenten

4

Edukt 2

HCID 944Nitric AcidHCID 19792116HCID 19792116, Verbindung

Produkt 1

HCID 19792129HCID 19792129, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7918Acetic AnhydrideLösungsmittel

Versuchsvorschrift

To a solution of methyl 5-chloro-2-valerylaminobenzoate (13.4 g) in acetic anhydride (10 ml) was added dropwise, while stirring under ice-cooling, fuming nitric acid. The mixture was stirred for one hour at room temperature, then there was added ice water. The mixture was allowed to stand to give crystals. Recrystallization from isopropyl ether afforded pale yellow crystals (9.5 g, 61%), m.p. 84-85° C.

Aufarbeitung

  1. temperaturecooling
  2. stirringThe mixture was stirred for one hour at room temperature
  3. customto give crystals
  4. customRecrystallization from isopropyl ether afforded pale yellow crystals (9.5 g, 61%), m.p. 84-85° C.

Quellen und Nachweise

ORD-Eintrag
ord-d6ae6d71e9d241edbda47ca09678da74
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05250554

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