Butylamine → 2-(Butylamino)nicotinonitrile

HRID 1655582Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1655582
[CH:1]1[CH:6]=[N:5][C:4](Cl)=[C:3]([C:8]#[N:9])[CH:2]=1.[CH2:10]([NH2:14])[CH2:11][CH2:12][CH3:13]>C(O)(C)C>[CH2:10]([NH:14][C:4]1[C:3]([C:8]#[N:9])=[CH:2][CH:1]=[CH:6][N:5]=1)[CH2:11][CH2:12][CH3:13]

Komponenten

4

Edukt 2

HCID 8007ButylamineHCID 810792-Chloronicotinonitrile

Produkt 1

HCID 126029792-(Butylamino)nicotinonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

2-Chloronicotinitrile (1.30 g, 9.60 mmol) was refluxed with 3 mL of n-butylamine and 10 mL of isopropyl alcohol overnight. The solvents were removed in vacuo and the residue obtained chromatographed on silica gel eluting with 2:1 hexane/ethyl acetate to give 1.6 g of the title compound.

Aufarbeitung

  1. customThe solvents were removed in vacuo
  2. customthe residue obtained
  3. customchromatographed on silica gel eluting with 2:1 hexane/ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-3654888df14242feb8137a91165712be
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05250548

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