4-Hydroxymethylpyridine → HCID 19787879, Verbindung

HRID 1656510Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1656510
[NH2:1][C:2]1[C:7](=[O:8])[N:6]([CH2:9][C:10]([NH:12][CH:13]([CH:27]([CH3:29])[CH3:28])[CH:14]([O:19][Si:20]([C:23]([CH3:26])([CH3:25])[CH3:24])([CH3:22])[CH3:21])[C:15]([F:18])([F:17])[F:16])=[O:11])[C:5]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[N:4][CH:3]=1.Cl[C:37](Cl)([O:39][C:40](=[O:46])OC(Cl)(Cl)Cl)Cl.[N:48]1[CH:53]=[CH:52][C:51](CO)=[CH:50][CH:49]=1.C(=O)(O)[O-].[Na+]>ClCCl.C(N(CC)CC)C>[O:8]=[C:7]1[N:6]([CH2:9][C:10]([NH:12][CH:13]([CH:27]([CH3:29])[CH3:28])[CH:14]([O:19][Si:20]([C:23]([CH3:26])([CH3:24])[CH3:25])([CH3:21])[CH3:22])[C:15]([F:18])([F:17])[F:16])=[O:11])[C:5]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)=[N:4][CH:3]=[C:2]1[NH:1][C:40]([O:39][CH2:37][C:51]1[CH:52]=[CH:53][N:48]=[CH:49][CH:50]=1)=[O:46]

Komponenten

7

Edukt 4

HCID 114724-HydroxymethylpyridineHCID 94429TriphosgeneHCID 516892Sodium BicarbonateHCID 19787914HCID 19787914, Verbindung

Produkt 1

HCID 19787879HCID 19787879, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

To a solution of 2-(5-amino-6-oxo-2-phenyl-1,6-dihydro-1-pyrimidinyl)-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide (1.1 g) and triphosgene (0.93 g) in dichloromethane at 0° C. was added triethylamine (2.0 mL) and the resulting solution was allowed to stir for 0.5 h. To this solution was added 4-pyridylcarbinol and the resulting solution allowed to stir overnight. The solution was poured into saturated aqueous sodium bicarbonate solution and the product was extracted into dichloromethane. The organic solution was washed (saturated aqueous sodium bicarbonate, water), dried, and evaporated. The resulting oil was purified by chromatography, with methanol:dichloromethane (5:95) as the eluent, to provide 2-[6-oxo-2-phenyl-5-(4-pyridylmethoxycarbonylamino)-1,6-dihydro-1-pyrimidinyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide as a white solid (0.9 g); TLC: Rf =0.4, methanol:dichloromethane (5:95).

Aufarbeitung

  1. stirringto stir overnight
  2. extractionthe product was extracted into dichloromethane
  3. washThe organic solution was washed (saturated aqueous sodium bicarbonate, water)
  4. customdried
  5. customevaporated
  6. customThe resulting oil was purified by chromatography, with methanol:dichloromethane (5:95) as the eluent

Quellen und Nachweise

ORD-Eintrag
ord-75d14d6d6c7144da94efdacd8b12f165
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05254558

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