2-Bromobenzyl bromide → 1-Bromo-2-(methoxymethyl)benzene

HRID 1656704

Reaktionsgleichung

Reaktionsgleichung von HRID 1656704
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[CH3:10][O-:11].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][O:11][CH3:10]

Komponenten

4

Edukt 2

HCID 769652-Bromobenzyl bromideHCID 10942334Sodium Methoxide

Produkt 1

HCID 129271621-Bromo-2-(methoxymethyl)benzeneAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

685 g (2.74 mol) of o-bromobenzyl bromide are refluxed together with 2.74 mol of a 30% strength sodium methylate solution in methanol for 15 hours. The mixture is cooled and then concentrated, the residue is taken up in ethyl acetate, and the solution is washed with water. The organic phase is dried over sodium sulfate and then concentrated. 478.2 g (87%) of product are obtained as a colorless liquid.

Aufarbeitung

  1. temperatureThe mixture is cooled
  2. concentrationconcentrated
  3. washthe solution is washed with water
  4. dry with materialThe organic phase is dried over sodium sulfate
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ac990156198e4b42a08f29931fbd0efa
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05254717

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