Hydrochloric Acid → 4-Ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide

HRID 1656898

Reaktionsgleichung

Reaktionsgleichung von HRID 1656898
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([S:14][CH3:15])[S:9][C:10]=1[C:11](Cl)=[O:12])=[O:5])[CH3:2].[C:16]([NH2:20])([CH3:19])([CH3:18])[CH3:17].Cl>ClCCl>[C:16]([NH:20][C:11]([C:10]1[S:9][C:8]([S:14][CH3:15])=[N:7][C:6]=1[C:4]([O:3][CH2:1][CH3:2])=[O:5])=[O:12])([CH3:19])([CH3:18])[CH3:17]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6385Tert-ButylamineHCID 150095674-Ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid chloride

Produkt 1

HCID 150095734-Ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamideAusbeute 100,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

3.50 g (13.2 mmol) of 4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid chloride was dissolved in 20 ml of dichloromethane and dripped, at 0° C., into a solution of 3.20 g (44 mmol) of tert-butylamine in 50 ml of dichloromethane. The mixture was allowed to warm up to room temperature and was then stirred for 14 hours. 100 ml of 10% strength hydrochloric acid was added and the organic phase was separated, washed with 50 ml of water and dried over sodium sulfate. The solvent was removed under reduced pressure, leaving 4.00 g (100%) of product as a yellow crystalline slurry.

Aufarbeitung

  1. customthe organic phase was separated
  2. washwashed with 50 ml of water
  3. dry with materialdried over sodium sulfate
  4. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f615a415704b4d12a7d5dae619e84c9f
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05256633

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