Sodium Chloride → HCID 19787485, Verbindung

HRID 1657280Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1657280
[OH-].[K+].O1CCCC1.[O:8]=[C:9]([CH3:20])[CH2:10][C:11]([CH:17]1[CH2:19][CH2:18]1)([CH:14]1[CH2:16][CH2:15]1)[CH:12]=O.[Cl-].[Na+]>C(OCC)C>[CH:14]1([C:11]2([CH:17]3[CH2:19][CH2:18]3)[CH2:10][C:9](=[O:8])[CH:20]=[CH:12]2)[CH2:16][CH2:15]1

Komponenten

6

Edukt 4

HCID 5234Sodium ChlorideHCID 8028TetrahydrofuranHCID 14797Potassium HydroxideHCID 19787455HCID 19787455, Verbindung

Produkt 1

HCID 19787485HCID 19787485, VerbindungAusbeute 91,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a mixture of 5% aqueous solution of potassium hydroxide (4.7 ml) and tetrahydrofuran (4.7 ml) was added a solution of 4-oxo-2,2-dicyclopropylpentanal (1.88 g) in diethyl ether (9.4 ml). The mixture was heated at 38° C. to 45° C. for 3 hours and cooled. The aqueous layer was saturated with sodium chloride. The mixture was extracted with diethyl ether and the extract was washed with brine, dried over sodium sulfate, and evaporated in vacuo. The residue was purified by distillation under reduced pressure to give 4,4-dicyclopropyl-2-cyclopenten-1-one (1.55 g).

Aufarbeitung

  1. temperatureThe mixture was heated at 38° C. to 45° C. for 3 hours
  2. temperaturecooled
  3. extractionThe mixture was extracted with diethyl ether
  4. washthe extract was washed with brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated in vacuo
  7. distillationThe residue was purified by distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-49ef4a14f04d4d5a9d77b0cc27590ba9
Quelldatensatz
uspto-grants-1993_10
Patentnummer
US05256824

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