Sodium hydride → 3,4-dihydro-5-methyl-2-[1-(5-methyl-1H-imidazol-4-yl)ethyl]pyrimido[1,6-a]-indol-1(2H)-one

Temperatur

5 °C

To a solution of 3,4-dihydro-5-methylpyrimido[1,6-a]-indol-1(2H)-one (1.88 g) in N,N-dimethylformamide (30 ml) was added sodium hydride (60% in mineral oil 1.12 g) at 5° C. After being stirred at 5° C. for 30 minutes, 4-(2-chloroethyl)-5-methyl-1H-imidazole hydrochloride (2.17 g) in N,N-dimethylformamide (30 ml) was added dropwise over 20 minutes. The mixture was stirred at 5° C. for 30 minutes and at ambient temperature for 16 hours. The reaction mixture was diluted with chilled water and extracted with a mixture of ethyl acetate and tetrahydrofuran (2:1, 30 ml×2). The organic layer was washed with brine, dried over anhydrous magnesium sulfate, and evaporated in vacuo. The residue was purified by silica gel column chromatography (3%-methanol-chloroform) to give 3,4-dihydro-5-methyl-2-[1-(5-methyl-1H-imidazol-4-yl)ethyl]pyrimido[1,6-a]indol-1(2H)-one as a powder.

1. stirringThe mixture was stirred at 5° C. for 30 minutes and at ambient temperature for 16 hours
2. extractionextracted with a mixture of ethyl acetate and tetrahydrofuran (2:1, 30 ml×2)
3. washThe organic layer was washed with brine
4. dry with materialdried over anhydrous magnesium sulfate
5. customevaporated in vacuo
6. customThe residue was purified by silica gel column chromatography (3%-methanol-chloroform)

ORD-Eintrag

ord-893495ef6b9948ff8506616dfb8c8cda

Quelldatensatz

uspto-grants-1993_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05256780