Acetic Acid → HCID 12883909, Verbindung

HRID 1658119Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1658119
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:11]=[CH:12][C:13]3[C:19](=[O:20])[C:18]([C:21]([OH:23])=[O:22])=[CH:17][NH:16][C:14]=3[N:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].S(OCC)(O[CH2:28][CH3:29])(=O)=O.C(O)(=O)C>C(=O)([O-])[O-].[Na+].[Na+]>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:11]=[CH:12][C:13]3[C:19](=[O:20])[C:18]([C:21]([OH:23])=[O:22])=[CH:17][N:16]([CH2:28][CH3:29])[C:14]=3[N:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 6163Diethyl SulfateHCID 128507552-(4-Acetyl-1-piperazinyl)-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid

Produkt 1

HCID 12883909HCID 12883909, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 10340Sodium CarbonateLösungsmittel

Versuchsvorschrift

To a solution of 0.45 g of 2-(4-acetyl-1-piperazinyl)-5,8-dihydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylic acid in 30 ml of sodium carbonate was added two 0.5 ml portions of diethyl sulfate with stirring at room temperature. After the completion of the reaction the mixture was neutralized with acetic acid. The precipitate resulted was collected and recrystallized from dimthylformamide to yield 0.4 g of the product, m.p. 298° - 300°C.

Aufarbeitung

  1. customAfter the completion of the reaction the mixture
  2. customThe precipitate resulted
  3. customwas collected
  4. customrecrystallized from dimthylformamide

Quellen und Nachweise

ORD-Eintrag
ord-bc368523f23642bbb9c0d7feac13cecf
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03962443

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