NaNCO → N-(2,3-Dihydro-1-benzofuran-5-yl)-N-propan-2-ylurea

HRID 1658283Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1658283
[CH:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]2[O:12][CH2:11][CH2:10][C:9]=2[CH:13]=1)([CH3:3])[CH3:2].[N-:14]=[C:15]=[O:16].[Na+]>C(O)(=O)C>[CH:1]([N:4]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][CH2:11][CH2:10][C:9]=2[CH:13]=1)[C:15]([NH2:14])=[O:16])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 11051568NaNCOHCID 21529005N-isopropyl-2,3-dihydro-5-benzofuranamine

Produkt 1

HCID 21529015N-(2,3-Dihydro-1-benzofuran-5-yl)-N-propan-2-ylurea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of 14.2 g. of N-isopropyl-2,3-dihydro-5-benzofuranamine in 300 ml. of glacial acetic acid, cooled to 15°±5°C. is added 4.9 g. of sodium isocyanate. The mixture is stirred at room temperature for 18 hours and then concentrated in vacuo. The residue is treated with 200 ml. of 2N sodium hydroxide solution and then extracted twice with chloroform. The combined chloroform extracts are dried with anhydrous magnesium fulfate, filtered and concentrated in vacuo to obtain an oil of 1-isopropyl-1-(2,3-dihydro-5-benzofuranyl)urea.

Aufarbeitung

  1. additionis added 4.9 g
  2. concentrationconcentrated in vacuo
  3. additionThe residue is treated with 200 ml
  4. extractionof 2N sodium hydroxide solution and then extracted twice with chloroform
  5. dry with materialThe combined chloroform extracts are dried with anhydrous magnesium fulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fbe4d884e36d4e7abed926bfcffcb84c
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03963717

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