Formaldehyde → N-(Hydroxymethyl)-2-(thiophen-2-yl)acetamide

HRID 1658690

Reaktionsgleichung

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH2:9])=[O:8].C=O.[C:12](=O)([O-])[O-:13].[K+].[K+]>>[OH:13][CH2:12][NH:9][C:7](=[O:8])[CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1

Komponenten

Edukt 3

HCID 712Formaldehyde

HCID 11430Potassium Carbonate

HCID 78208Thiophen-2-acetamide

Produkt 1

HCID 21452354N-(Hydroxymethyl)-2-(thiophen-2-yl)acetamide

Reaktionsbedingungen

Temperatur: 0 °C

Versuchsvorschrift

A mixture of 2-thienylacetamide, formaldehyde solution (37%, 1 equivalent) and a catalytic amount of potassium carbonate is warmed on a steam bath until a homogeneous solution is obtained. The solution is cooled to 0° C. overnight and the resulting solid collected by filtration.

Aufarbeitung

customis obtained
filtrationthe resulting solid collected by filtration

Quellen und Nachweise

ORD-Eintrag: ord-8c4868c90c71407c9c7cef1a16ef409c
Quelldatensatz: uspto-grants-1976_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US03966710

Verknüpfte Notizen

Wird geladen…