HCID 21505599, Verbindung → HCID 21525672, Verbindung

HRID 1658807Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1658807
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:23])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH:16]=[C:15]([C:18]3[O:19][CH:20]=[CH:21][N:22]=3)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1>[Pd].C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:23])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[O:19][CH:20]=[CH:21][N:22]=3)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 21505599HCID 21505599, Verbindung

Produkt 1

HCID 21525672HCID 21525672, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A 0.32 g. portion of 3,6-dihydro-α-(p-fluorophenyl)-4-(2-oxazolyl)-1(2H)-pyridinebutanol, prepared as described in Example 15, is dissolved in 10 ml. of ethanol and 0.1 g. of palladium on carbon catalyst is added. The mixture is reduced at room temperature and pressure for 4 hours and then filtered. The filtrate is evaporated giving an oil which solidifies to a white solid. This solid is recrystallized twice from acetonitrile, m.p. 99°-100°C.

Aufarbeitung

  1. dissolutionis dissolved in 10 ml
  2. customis reduced at room temperature
  3. filtrationfiltered
  4. customThe filtrate is evaporated
  5. customgiving an oil which
  6. customThis solid is recrystallized twice from acetonitrile, m.p. 99°-100°C.

Quellen und Nachweise

ORD-Eintrag
ord-de1a2b649bd7474c912c0e76e4af0c36
Quelldatensatz
uspto-grants-1976_06
Patentnummer
US03966748

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