Ammonia → 8-Methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid

HRID 1660018

Reaktionsgleichung

Reaktionsgleichung von HRID 1660018
[NH3:1].[CH3:2][O:3][C:4]1[C:9]2[O:10][CH2:11][CH2:12][O:13][C:8]=2[C:7]([C:14]([OH:16])=[O:15])=[CH:6][C:5]=1[S:17](Cl)(=[O:19])=[O:18]>O>[CH3:2][O:3][C:4]1[C:9]2[O:10][CH2:11][CH2:12][O:13][C:8]=2[C:7]([C:14]([OH:16])=[O:15])=[CH:6][C:5]=1[S:17](=[O:19])(=[O:18])[NH2:1]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 205447488-Methoxy-7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid

Produkt 1

HCID 205446908-Methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acidAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

300 g of 34% ammonia were introduced into a balloon flask provided with an agitator and a thermometer and then 159 g of 8-methoxy-7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid were added in portions, the temperature being maintained at from 0°-5° C. The mixture was agitated and then the precipitate was dissolved in water. The solution was filtered and treated with 280 cm3 of concentrated hydrochloric acid. The precipitate was dried off, washed and dried. 118 g of 8-methoxy-7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid were obtained (M.P.: 247°-248° C.; yield: 82%).

Aufarbeitung

  1. customprovided with an agitator
  2. temperaturethe temperature being maintained at from 0°-5° C
  3. filtrationThe solution was filtered
  4. additiontreated with 280 cm3 of concentrated hydrochloric acid
  5. customThe precipitate was dried off
  6. washwashed
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-71d72980b68f4c39988f7ceb4f0e8973
Quelldatensatz
uspto-grants-1981_12
Patentnummer
US04306072

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