Carisoprodol → HCID 86761421, Verbindung

HRID 1660668Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1660668
[CH3:1][CH2:2][CH2:3][C:4]([CH2:11][O:12][C:13]([NH:15][CH:16]([CH3:18])[CH3:17])=[O:14])([CH2:6][O:7][C:8]([NH2:10])=[O:9])[CH3:5].[CH:19]1[CH:20]=[CH:21][C:22]([NH:29][C:30]2[C:31]([Cl:37])=[CH:32][CH:33]=[CH:34][C:35]=2[Cl:36])=[C:23]([CH2:25][C:26]([O-:28])=[O:27])[CH:24]=1.[Na+]>>[CH3:1][CH2:2][CH2:3][C:4]([CH2:11][O:12][C:13]([NH:15][CH:16]([CH3:17])[CH3:18])=[O:14])([CH2:6][O:7][C:8]([NH2:10])=[O:9])[CH3:5].[CH:19]1[CH:20]=[CH:21][C:22]([NH:29][C:30]2[C:35]([Cl:36])=[CH:34][CH:33]=[CH:32][C:31]=2[Cl:37])=[C:23]([CH2:25][C:26]([OH:28])=[O:27])[CH:24]=1

Komponenten

3

Edukt 2

HCID 2576CarisoprodolHCID 5018304Diclofenac sodium

Produkt 1

HCID 86761421HCID 86761421, Verbindung

Versuchsvorschrift

A second composition to cover the perforated coated cores is prepared as follows: carisoprodol, diclofenac sodium, a diluent and a hinder are placed in a high shear mixer and mix for 5 minutes. The granulation process is initiated by the gradual addition of a granulating solution containing a plasticizer and purified water to the high shear with continuous blending to produce a wet blend. Next, the wet blend is granulated and dried at 40-500 for 20 minutes in a fluid bed to remove the water. Then, the dry granules are screened through a 20 USP mesh screen for size reduction. Next, the screened granules are mixed with a glidant and a lubricant, that have been previously passed through a 60 mesh screen, in a V-Blender during 5 minutes. The granulate is applied over the perforated cores through compression to obtain carisoprodol-diclofenac coated osmotic devices. The coated device has an outer diameter of about 14 mm.

Aufarbeitung

  1. customis prepared
  2. additionmix for 5 minutes
  3. additionThe granulation process is initiated by the gradual addition of a granulating solution
  4. additioncontaining a plasticizer
  5. custompurified water to the high shear with continuous blending
  6. customto produce a wet blend
  7. customdried at 40-500 for 20 minutes in a fluid bed
  8. customto remove the water
  9. additionNext, the screened granules are mixed with a glidant

Quellen und Nachweise

ORD-Eintrag
ord-89c5569bfeb34ed09ec983411c004cca
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08029822B2

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