HCID 67021301, Verbindung → HCID 60925354, Verbindung

HRID 1660953Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1660953
[CH3:1][N:2]([CH:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1)[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13]>CCO.[Pd]>[CH3:1][N:2]([CH:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1)[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[C:12]([F:15])([F:13])[F:14]

Komponenten

4

Edukt 1

HCID 67021301HCID 67021301, Verbindung

Produkt 1

HCID 60925354HCID 60925354, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of methyl-(1-methyl-piperidin-4-yl)-(4-nitro-2-trifluoromethyl-phenyl)amine (0.812 g, 2.56 mmol) and Pd/C (10%) (0.200 g) in EtOH (20 mL) is stirred for 1 h 25 min at rt, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of Celite and concentrated to afford the title compound as a yellow oil: ES-MS: 288.1 [M+H]+; single peak at tR=1.50 min (System 1).

Aufarbeitung

  1. filtrationThe reaction mixture is filtered through a pad of Celite
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-4b1c413bac394ba096db4a93022392d3
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030311B2

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