2,2-Dimethyl-1,3-dioxane-4,6-dione → 2,2-Dimethyl-5-(1-methylethylidene)-1,3-dioxane-4,6-dione

Reaktionsgleichung

[CH3:1][C:2]1([CH3:10])[O:7][C:6](=[O:8])[CH2:5][C:4](=[O:9])[O:3]1.[CH2:11](OC1C=C(COC2C=C([C@@H](C)CC(O)=O)C=CC=2)C=CC=1C1C=C(OC)C=CC=1F)[CH2:12][CH2:13]C>>[CH3:1][C:2]1([CH3:10])[O:7][C:6](=[O:8])[C:5](=[C:12]([CH3:13])[CH3:11])[C:4](=[O:9])[O:3]1

Komponenten

Edukt 2

HCID 162492,2-Dimethyl-1,3-dioxane-4,6-dione

HCID 57705600(3S)-3-(3-(((2-(butyloxy)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methyl)oxy)phenyl)butanoic acid

Produkt 1

HCID 752182,2-Dimethyl-5-(1-methylethylidene)-1,3-dioxane-4,6-dione

Versuchsvorschrift

The 2,2-dimethyl-5-(propan-2-ylidene)-1,3-dioxane-4,6-dione (85.B) was prepared from 2,2-dimethyl-1,3-dioxane-4,6-dione 85.A (commercially available from Aldrich) via the same procedure described in Vogt, P. F.; et. al.; Synthetic Communications; 2001, (5); pp. 679-684.

Quellen und Nachweise

ORD-Eintrag: ord-360fe80e123e419ab6cbcd1ae0848ceb
Quelldatensatz: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08030354B2

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