Sodium Sulfate → 2-(3-Bromo-4-methoxyphenyl)ethanol

HRID 1662754Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1662754
[H-].[H-].[H-].[H-].[Li+].[Al+3].C([O:9][C:10](=O)[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[C:14]([Br:20])[CH:13]=1)C.[O-]S([O-])(=O)=O.[Na+].[Na+]>C1COCC1>[Br:20][C:14]1[CH:13]=[C:12]([CH2:11][CH2:10][OH:9])[CH:17]=[CH:16][C:15]=1[O:18][CH3:19]

Komponenten

5

Edukt 3

HCID 24436Sodium SulfateHCID 21226445Aluminium lithium hydrideHCID 57419861Ethyl 3-bromo-4-methoxyphenylacetate

Produkt 1

HCID 230022542-(3-Bromo-4-methoxyphenyl)ethanolAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of 10.7 g of LAH in THF (600 ml) was added dropwise a solution of 70.0 g of ethyl(3-bromo-4-methoxyphenyl)acetate in THF (200 ml) at an internal temperature of −12 to −3° C. After stirring at an internal of 0° C. or lower for one hour, Na2SO4/10 hydrate was added slowly. After foaming ended, filtration was carried out. The filtrate was concentrated under reduced pressure to obtain 45.0 g of the title compound (light yellow oil).

Aufarbeitung

  1. filtrationfiltration
  2. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e500808f0c544d0c9585c10d367da5a9
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08030499B2

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