Hydrochloric Acid → 4-(1-Benzyl-piperidin-4-ylidenemethyl)-benzimidic acid ethyl ester

HRID 1663237

Reaktionsgleichung

Reaktionsgleichung von HRID 1663237
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]2[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(Cl)Cl.Cl.[CH2:28]([OH:30])[CH3:29]>>[CH2:28]([O:30][C:19](=[NH:20])[C:18]1[CH:17]=[CH:16][C:15]([CH:14]=[C:11]2[CH2:12][CH2:13][N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:9][CH2:10]2)=[CH:22][CH:21]=1)[CH3:29]

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 6212ChloroformHCID 674356554-(1-Benzyl-piperidin-4-ylidenemethyl)-benzonitrile

Produkt 1

HCID 674362034-(1-Benzyl-piperidin-4-ylidenemethyl)-benzimidic acid ethyl esterAusbeute 92,4 %

Versuchsvorschrift

A mixture of 4-(1-benzyl-piperidin-4-ylidenemethyl)-benzonitrile (14 g, 48.6 mmol), chloroform (10 mL) and 6 M hydrogen chloride in ethanol (300 mL) was stirred at room temperature for 48 hours. The solution was concentrated in vacuo, the remaining solid was repeatedly dissolved in ethanol (400 mL) and concentrated in vacuo to yield 16.4 g (92.4%) of the title compound, which was used in the next steps without further purification.

Aufarbeitung

  1. concentrationThe solution was concentrated in vacuo
  2. dissolutionthe remaining solid was repeatedly dissolved in ethanol (400 mL)
  3. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-491d251fbdd64308bae3659291581e66
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08034827B2

Verknüpfte Notizen

Wird geladen…