Pyridine → HCID 67435761, Verbindung

HRID 1663390Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1663390
[NH2:1][C:2]1[CH:3]=[C:4]([CH:36]=[CH:37][CH:38]=1)[CH2:5][O:6][C:7]1[C:12]([Br:13])=[CH:11][C:10]([CH:14]2[C:23]3[C:22](=[O:24])[CH2:21][CH:20]([CH2:25][CH2:26][CH3:27])[CH2:19][C:18]=3[NH:17][C:16]([CH3:28])=[C:15]2[C:29]#[N:30])=[CH:9][C:8]=1[NH:31][S:32]([CH3:35])(=[O:34])=[O:33].N1C=CC=CC=1.[CH3:45][S:46](Cl)(=[O:48])=[O:47]>ClCCl.C(OCC)(=O)C>[Br:13][C:12]1[C:7]([O:6][CH2:5][C:4]2[CH:36]=[CH:37][CH:38]=[C:2]([NH:1][S:46]([CH3:45])(=[O:48])=[O:47])[CH:3]=2)=[C:8]([NH:31][S:32]([CH3:35])(=[O:34])=[O:33])[CH:9]=[C:10]([CH:14]2[C:23]3[C:22](=[O:24])[CH2:21][CH:20]([CH2:25][CH2:26][CH3:27])[CH2:19][C:18]=3[NH:17][C:16]([CH3:28])=[C:15]2[C:29]#[N:30])[CH:11]=1

Komponenten

6

Edukt 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 67434762HCID 67434762, Verbindung

Produkt 1

HCID 67435761HCID 67435761, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of N-[2-(3-amino-benzyloxy)-3-bromo-5-(3-cyano-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinolin-4-yl)-phenyl]-methanesulfonamide (709 mg) and pyridine (286 μl) in dichloromethane (20 ml) was added methanesulfonyl chloride (138 μl). After stirring for 18 h, the mixture was diluted with ethyl acetate and washed with water. The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by preparative HPLC (Method B).

Aufarbeitung

  1. washwashed with water
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customThe residue was purified by preparative HPLC (Method B)

Quellen und Nachweise

ORD-Eintrag
ord-975351b3708a465f85865e1f52495118
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08034945B2

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