2,5-Dimethyl-2H-pyrazole-3-carbonyl chloride → 3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}-4-fluorophenyl methyl carbonate

HRID 1663635

Reaktionsgleichung

Reaktionsgleichung von HRID 1663635
Cl.[C:2](=[O:14])([O:12][CH3:13])[O:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([NH2:11])[CH:5]=1.[CH3:15][N:16]1[C:20]([C:21](Cl)=[O:22])=[CH:19][C:18]([CH3:24])=[N:17]1>CN(C)C(=O)C>[C:2](=[O:14])([O:12][CH3:13])[O:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[C:6]([NH:11][C:21]([C:20]2[N:16]([CH3:15])[N:17]=[C:18]([CH3:24])[CH:19]=2)=[O:22])[CH:5]=1

Komponenten

4

Edukt 2

HCID 27362992,5-Dimethyl-2H-pyrazole-3-carbonyl chlorideHCID 574410313-Amino-4-fluorophenyl methyl carbonate hydrochloride

Produkt 1

HCID 575054333-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}-4-fluorophenyl methyl carbonateAusbeute 87,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

Using a solution of 3-amino-4-fluorophenyl methyl carbonate hydrochloride (740 mg, 3.34 mmol) and 1,3-dimethyl-1H-pyrazole-5-carbonylchloride (556 mg, 3.51 mmol) in N,N-dimethylacetamide (10 mL), and by a reaction in the same manner as in Example 148, the title compound (895 mg, 87%) was obtained as a white powder.

Aufarbeitung

  1. customby a reaction in the same manner as in Example 148

Quellen und Nachweise

ORD-Eintrag
ord-6630e95b25194dc8bb5852cbcbc69b09
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08034812B2

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