3-Isopropoxypropylamine → 3-(3-Isopropoxypropylsulfamoyl)benzoic acid

HRID 1665157Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1665157
[CH:1]([O:4][CH2:5][CH2:6][CH2:7][NH2:8])([CH3:3])[CH3:2].C(N(CC)C(C)C)(C)C.C[C:19]1[C:27]([S:28](Cl)(=[O:30])=[O:29])=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([OH:23])=[O:22]>C1COCC1>[CH:1]([O:4][CH2:5][CH2:6][CH2:7][NH:8][S:28]([C:27]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21]([OH:23])=[O:22])(=[O:30])=[O:29])([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 761943-IsopropoxypropylamineHCID 81531DiisopropylethylamineHCID 543955313-(Chlorosulfonyl)-2-methylbenzoic acid

Produkt 1

HCID 670865933-(3-Isopropoxypropylsulfamoyl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3-Isopropoxypropylamine (1.1 eq.) is dissolved in THF with stirring at room temperature. N,N-diisopropylethylamine (1 eq.) is added followed by methyl 3-(chlorosulfonyl)benzoic acid (1 eq.). The reaction mixture is stirred at room temperature for 2 hours before the solvent is evaporated in vacuo to yield the crude titled product.

Aufarbeitung

  1. stirringThe reaction mixture is stirred at room temperature for 2 hours before the solvent
  2. customis evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-29c88124b9164e18b1b5ff61293dca0e
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08039472B2

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