5,8,14-Triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaene → p-Toluenesulfonic acid

HRID 1665791

Reaktionsgleichung

Reaktionsgleichung von HRID 1665791
C1C=NC2C(N=1)=CC1C3CNCC(C=1C=2)C3.[S:17]([C:21]1[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=1)([O-:20])(=[O:19])=[O:18].C1C=NC2C(N=1)=CC1C3CNCC(C=1C=2)C3>>[C:24]1([CH3:25])[CH:23]=[CH:22][C:21]([S:17]([OH:20])(=[O:18])=[O:19])=[CH:27][CH:26]=1

Komponenten

3

Edukt 2

HCID 1703615,8,14-Triazatetracyclo[10.3.1.02,11.04,9]hexadeca-2,4,6,8,10-pentaeneHCID 86637773Varenicline Tosylate

Produkt 1

HCID 6101p-Toluenesulfonic acid

Versuchsvorschrift

Varenicline Tosylate can be prepared by combining Varenicline base, a solvent and p-Toluene sulfonic acid (p-TSA) to obtain a reaction mixture and precipitating Varenicline Tosylate from the reaction mixture. Preferably, the obtained Varenicline Tosylate is further recovered from the reaction mixture.

Quellen und Nachweise

ORD-Eintrag
ord-a043c6acb8064c67afa11162b50f2adf
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08039620B2

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