Potassium Carbonate → 2-Butoxy-7,8-dihydro-9-(3-[4-(4-methylbenzyl)piperazin-1-yl]propyl)-8-oxoadenine

HRID 1666200

Reaktionsgleichung

[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([NH:10][C:11](=[O:19])[N:12]2[CH2:15][CH2:16][CH2:17]Br)=[C:8]([NH2:20])[N:7]=1)[CH2:2][CH2:3][CH3:4].C(=O)([O-])[O-].[K+].[K+].[CH3:27][C:28]1[CH:40]=[CH:39][C:31]([CH2:32][N:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[CH:30][CH:29]=1>CN(C=O)C>[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([NH:10][C:11](=[O:19])[N:12]2[CH2:15][CH2:16][CH2:17][N:36]2[CH2:37][CH2:38][N:33]([CH2:32][C:31]3[CH:39]=[CH:40][C:28]([CH3:27])=[CH:29][CH:30]=3)[CH2:34][CH2:35]2)=[C:8]([NH2:20])[N:7]=1)[CH2:2][CH2:3][CH3:4]

Komponenten

Reaktionsbedingungen

Temperatur: 70 °C

Versuchsvorschrift

The compound (180 mg) obtained in Step (ii), potassium carbonate (140 mg) and 4-methylbenzylpiperazine (130 mg) were added to DMF (5 mL), and the mixture was stirred at 70° C. for 3 hours. The insoluble materials were collected by filtration, and the residue was purified by silica gel column chromatography (CHCl3:MeOH:28% NH3 aq.=100:3:2) to give the title compound (48 mg).

Aufarbeitung

filtrationThe insoluble materials were collected by filtration
customthe residue was purified by silica gel column chromatography (CHCl3:MeOH:28% NH3 aq.=100:3:2)

Quellen und Nachweise

ORD-Eintrag: ord-b86f59bebe9f499f8c4dc1a19f62f9de
Quelldatensatz: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08044056B2

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