HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → 2-Butoxy-7,8-dihydro-9-(3-[4-(4-methylbenzyl)piperazin-1-yl]propyl)-8-oxoadenine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 1-(4-Methylbenzyl)piperazine | HCID 764723 | — |
| Edukt | 2-Butoxy-9-(3-bromopropyl)-7,8-dihydro-8-oxoadenine | HCID 59288031 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 2-Butoxy-7,8-dihydro-9-(3-[4-(4-methylbenzyl)piperazin-1-yl]propyl)-8-oxoadenine | HCID 25014764 | 20,2% |
Reaktionsbedingungen
| Temperatur | 70 °C |
|---|
Reaktionsschritte
The compound (180 mg) obtained in Step (ii), potassium carbonate (140 mg) and 4-methylbenzylpiperazine (130 mg) were added to DMF (5 mL), and the mixture was stirred at 70° C. for 3 hours. The insoluble materials were collected by filtration, and the residue was purified by silica gel column chromatography (CHCl3:MeOH:28% NH3 aq.=100:3:2) to give the title compound (48 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08044056B2 |
| Quelldatensatz | uspto-grants-2011_10 |
| ORD ID | ord-b86f59bebe9f499f8c4dc1a19f62f9de |
| Quellennotiz | uspto-grants-2011_10 |