Pyridine → Phenyl 3-methylpyrazin-2-ylcarbamate

HRID 1666359

Reaktionsgleichung

Reaktionsgleichung von HRID 1666359
[NH2:1][C:2]1[C:7]([CH3:8])=[N:6][CH:5]=[CH:4][N:3]=1.CC#N.N1C=CC=CC=1.[C:18]1([O:24][C:25](Cl)=[O:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1COCC1>[CH3:8][C:7]1[C:2]([NH:1][C:25](=[O:26])[O:24][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:3][CH:4]=[CH:5][N:6]=1

Komponenten

6

Edukt 4

HCID 1049PyridineHCID 6342AcetonitrileHCID 15891Phenyl chloroformateHCID 3022842-Amino-3-methylpyrazine

Produkt 1

HCID 66875712Phenyl 3-methylpyrazin-2-ylcarbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

A solution of 2-amino-3-methyl-pyrazine (1.50 g, 1.37 mmol) in a mix of 1:2 THF:MeCN (30 mL), and pyridine (0.664 g, 1.44 mmol) was treated dropwise with phenylchloroformate (1.3 g, 1.44 mmol) in THF (10 mL). After stirring for 18 h, the reaction mixture was concentrated in vacuo to a solid and was used without further purification.

Aufarbeitung

  1. concentrationthe reaction mixture was concentrated in vacuo to a solid
  2. customwas used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-d151172da7374fd68c235531ce430bd0
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08044052B2

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