Ammonium Chloride → 1,8-Diazabicyclo[5.4.0]undec-7-ene hydrochloride
Reaktionsgleichung
[Cl-:1].[NH4+].[N:3]12[CH2:13][CH2:12][CH2:11][N:10]=[C:9]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]2>>[ClH:1].[N:3]12[CH2:13][CH2:12][CH2:11][N:10]=[C:9]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]2Komponenten
3
Versuchsvorschrift
26.8 g (0.5 mol) of ammonium chloride were introduced into a 500 ml stirred reactor fitted with nitrogen inlet and separate feed device and suspended in 200 ml of methanol. Over the course of 30 minutes 76.1 g (0.5 mol) of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) were added, where upon the reaction mixture was solubilized. The mixture was stirred for a further three hours and then the solvent was evaporated and the remaining solid dried in vacuo.
Aufarbeitung
- customfitted with nitrogen inlet
- customseparate feed device
- stirringThe mixture was stirred for a further three hours
- customthe solvent was evaporated
- customthe remaining solid dried in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-98ec0296fdab43dc989fdefe275d29e3
- Quelldatensatz
- uspto-grants-2011_10
- Patentnummer
- US08044120B2
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