Potassium Carbonate → [4-Benzyloxy-4'-(trifluoromethoxy)biphenyl-3-yl]acetic acid

Temperatur

80 °C

A mixture of 2-benzyloxy-5-bromophenylacetic acid (261 mg, 0.813 mmol), 4-(trifluoromethoxy)phenyl boronic acid (218 mg, 1.056 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (43 mg, 0.057 mmol), potassium carbonate (169 mg, 1.22 mmol), dioxane (4 ml) and water (0.5 ml) was stirred at 80° C. for 2 hours. The reaction mixture was cooled to room temperature, and the solvent was evaporated under reduced pressure. Ethyl acetate was added to the residue, and the solution was filtered through celite. The residue obtained by concentration of the filtrate under reduced pressure was purified by column chromatography on silica gel (n-hexane:ethyl acetate=3:2) to give the title compound (160 mg, 48.9%) as a white solid.

1. temperatureThe reaction mixture was cooled to room temperature
2. customthe solvent was evaporated under reduced pressure
3. additionEthyl acetate was added to the residue
4. filtrationthe solution was filtered through celite
5. customThe residue obtained by concentration of the filtrate under reduced pressure
6. customwas purified by column chromatography on silica gel (n-hexane:ethyl acetate=3:2)

ORD-Eintrag

ord-e4c22962861d4369a18d15a21b4133ec

Quelldatensatz

uspto-grants-2011_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08044236B2