Bromine → 2-Bromo-1-[2-(trifluoromethyl)phenyl]ethan-1-one

HRID 1667651Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1667651
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:11])[CH3:10].[Br:14]Br>ClCCl>[Br:14][CH2:10][C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:12])([F:13])[F:1])=[O:11]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 870952'-(Trifluoromethyl)acetophenone

Produkt 1

HCID 27784302-Bromo-1-[2-(trifluoromethyl)phenyl]ethan-1-oneAusbeute 92,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 20.00 g (0.11 mole) of 2′-(trifluoromethyl)acetophenone in 200 mL of dichloromethane was added 5.5 mL (0.11 mole) of bromine over 90 minutes. A stream of nitrogen was bubbled through the reaction mixture for 15 minutes. The mixture solvent was removed under reduced pressure. The residue was dissolved with ethanol, and then concentrated under reduced pressure to give 27.25 g of 2-bromo-1-(2-trifluoromethyl-phenyl)-ethanone as a yellow oil, which was used in the next step without further purification.

Aufarbeitung

  1. customA stream of nitrogen was bubbled through the reaction mixture for 15 minutes
  2. customThe mixture solvent was removed under reduced pressure
  3. dissolutionThe residue was dissolved with ethanol
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0b0a9f6db9024e3eb37d062e137f3e1f
Quelldatensatz
uspto-grants-2011_10
Patentnummer
US08044213B2

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