3-(Trifluoromethyl)aniline → 6-Methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinolin-l-amine

HRID 1668912

Reaktionsgleichung

Reaktionsgleichung von HRID 1668912
Cl[C:2]1[C:11]2[C:6](=[C:7]([N+:13]([O-:15])=[O:14])[C:8]([CH3:12])=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[F:16][C:17]([F:26])([F:25])[C:18]1[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=1>C(O)(C)C>[CH3:12][C:8]1[C:7]([N+:13]([O-:15])=[O:14])=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]([NH:24][C:20]1[CH:21]=[CH:22][CH:23]=[C:18]([C:17]([F:16])([F:25])[F:26])[CH:19]=1)=[N:3][CH:4]=[CH:5]2

Komponenten

4

Edukt 2

HCID 73753-(Trifluoromethyl)anilineHCID 226222211-Chloro-6-methyl-5-nitroisoquinoline

Produkt 1

HCID 673394766-Methyl-5-nitro-N-(3-(trifluoromethyl)phenyl)isoquinolin-l-amineAusbeute 81,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
180 °C

Versuchsvorschrift

1-Chloro-6-methyl-5-nitroisoquinoline (0.25 g, 1.1 mmol) and 3-(trifluoromethyl)benzenamine (0.17 mL, 1.3 mmol) were added to a microwave tube containing 3 mL of isopropanol. The tube was capped and heated at 180° C. for 1500 seconds. The volatiles were removed in vacuo. The residue was taken up in DCM and washed with saturated NaHCO3. The organic layer was dried with sodium sulfate and purified by column chromatography on silica gel using a gradient of 10 to 40% of ethyl acetate in hexanes to give the product as an orange solid (0.31 g, 79%). MS (M+H)+ 348.

Aufarbeitung

  1. customThe tube was capped
  2. customThe volatiles were removed in vacuo
  3. washwashed with saturated NaHCO3
  4. dry with materialThe organic layer was dried with sodium sulfate
  5. custompurified by column chromatography on silica gel using a gradient of 10 to 40% of ethyl acetate in hexanes

Quellen und Nachweise

ORD-Eintrag
ord-de34fa00b71f4e169f579d51e8639b72
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07989461B2

Verknüpfte Notizen

Wird geladen…