Water → 2-chloro-N-(1-(3,4-dichlorophenyl)-1H-pyrazol-3-yl)acetamide

HRID 1669532Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1669532
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[CH:12][C:11]([NH2:14])=[N:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].C(N(CC)CC)C.[Cl:22][CH2:23][C:24](Cl)=[O:25].O>O1CCCC1>[Cl:22][CH2:23][C:24]([NH:14][C:11]1[CH:12]=[CH:13][N:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[N:10]=1)=[O:25]

Komponenten

6

Edukt 4

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 234642861-(3,4-Dichlorophenyl)-1H-pyrazol-3-amine

Produkt 1

HCID 577054132-chloro-N-(1-(3,4-dichlorophenyl)-1H-pyrazol-3-yl)acetamideAusbeute 92,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution, ice cooled, of 1-(3,4-dichlorophenyl)-1H-pyrazol-3-amine (0.36 g, 1.59 mmol) and triethylamine (0.24 g, 2.38 mmol) in dry tetrahydrofurane (5 ml), 2-chloroacetyl chloride (0.2 g, 1.79 mmol) was added. The mixture was stirred overnight at room temperature, water added and the organic solvent evaporated in vacuo. The resulting suspension was filtered and dried yielding 0.45 g of 2-chloro-N-(1-(3,4-dichlorophenyl)-1H-pyrazol-3-yl)acetamide as a beige colour solid.

Aufarbeitung

  1. additionwas added
  2. customthe organic solvent evaporated in vacuo
  3. filtrationThe resulting suspension was filtered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ef93c1bb995f44b983e325f7700c6b91
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07989485B2

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