3-Methyl-5-(4-methylphenyl)isoxazole → 3-Amino-1-(4-methylphenyl)but-2-en-1-one

HRID 1669801Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1669801
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[O:4][N:3]=1>[Pt](=O)=O.C(O)C>[NH2:3][C:2]([CH3:1])=[CH:6][C:5]([C:7]1[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][CH:12]=1)=[O:4]

Komponenten

4

Edukt 1

HCID 103521723-Methyl-5-(4-methylphenyl)isoxazole

Produkt 1

HCID 673437903-Amino-1-(4-methylphenyl)but-2-en-1-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

3-Methyl-5-(4-methylphenyl)isoxazole (1 g, 5.77 mmol) is introduced into 20 ml of ethanol, platinum(IV) oxide catalyst (100 mg) is added, and the mixture is then hydrogenated under atmospheric hydrogen for 12 h. The catalyst is filtered off and the filtrate is concentrated. 1.02 g (100% of theory) of the title compound are obtained as a white solid.

Aufarbeitung

  1. additionis added
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated

Quellen und Nachweise

ORD-Eintrag
ord-27a6cf0c335441e7ac03812465a2a108
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07989633B2

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