Hydrochloric Acid → 2-Carbamoyl-6-nitrobenzoic Acid

HRID 1671704

Reaktionsgleichung

Reaktionsgleichung von HRID 1671704
[N+:1]([C:4]1[CH:14]=[CH:13][CH:12]=[C:6]2[C:7]([NH:9][C:10](=[O:11])[C:5]=12)=[O:8])([O-:3])=[O:2].[OH-:15].[Na+].Cl>O>[N+:1]([C:4]1[CH:14]=[CH:13][CH:12]=[C:6]([C:7]([NH2:9])=[O:8])[C:5]=1[C:10]([OH:15])=[O:11])([O-:3])=[O:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 117793-NitrophthalimideHCID 14798Sodium Hydroxide

Produkt 1

HCID 45927482-Carbamoyl-6-nitrobenzoic AcidAusbeute 73 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
5 °C

Versuchsvorschrift

A suspension of 57.6 g of 3-nitro-phthalimide (0.3 mol) in 672 g of water is cooled to 5° C. 80 g of 30% sodium hydroxide solution (0.6 mol, 2 equivalents) are added in the shortest possible time. After 2 hours at 5° C., the reaction mixture is added at 5° C. to 65 g of 32% hydrochloric acid solution (0.57 mol, 1.9 equivalents), which is diluted beforehand with 72 ml of water. The pH value is adjusted to 2-2.5 and the crude product which crystallises out is filtered off and washed twice with water. 6-Nitrophthalamic acid is obtained in a yield of 73%.

Aufarbeitung

  1. customthe crude product which crystallises out
  2. filtrationis filtered off
  3. washwashed twice with water

Quellen und Nachweise

ORD-Eintrag
ord-5b60995a9eee40349be5237e5b600b66
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07994341B2

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