Hydrochloric Acid → 3-Hydroxy-4-methyl-2-nitrobenzoic acid

HRID 1672477

Reaktionsgleichung

Reaktionsgleichung von HRID 1672477
C(N[C:5]1[C:6]([N+:15]([O-:17])=[O:16])=[C:7]([CH:11]=[CH:12][C:13]=1[CH3:14])[C:8]([OH:10])=[O:9])(=O)C.[OH-:18].[K+].Cl>O>[OH:18][C:5]1[C:6]([N+:15]([O-:17])=[O:16])=[C:7]([CH:11]=[CH:12][C:13]=1[CH3:14])[C:8]([OH:10])=[O:9]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 2434333-Acetamido-4-methyl-2-nitrobenzoic acid

Produkt 1

HCID 813743-Hydroxy-4-methyl-2-nitrobenzoic acidAusbeute 93,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 3-(acetylamino)-4-methyl-2-nitrobenzoic acid (237.5 g, 0.997 mol) and KOH (451.2 g, 8.04 mol) in water (2830 mL) was refluxed for 48 h. The dark red solution was cooled and acidified to pH 1 with concentrated HCl. The yellow solid was filtered and re-crystallized from water (1800 mL) to give the title compound (183 g, 93.4%) as a yellow solid.

Aufarbeitung

  1. temperatureThe dark red solution was cooled
  2. filtrationThe yellow solid was filtered
  3. customre-crystallized from water (1800 mL)

Quellen und Nachweise

ORD-Eintrag
ord-38c31f1419744cd699942a50b6d9a0af
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07998978B2

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