[2-(2-Chlorobenzyloxy)phenyl]methanol → [2-(2-Chlorobenzyloxy)benzyl]triphenylphosphonium bromide

Beteiligte Stoffe

Reaktionsschritte

A solution of 3.775 g (15.18 mmol) of [2-(2-chlorobenzyloxy)phenyl]methanol from Example 78A in 60 ml of acetonitrile is mixed with 4.949 g (14.42 mmol) of triphenylphosphonium hydrobromide and heated to reflux for 3 hours. The reaction solution is then concentrated to dryness, and the resulting oil is taken up and triturated in diethyl ether. The product crystallizes as a white solid during this. After filtration, the solid is dried in a drying oven at 50° C. overnight. 8.247 g (91% yield) of crystalline product are obtained.

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