Water → 5-(3-iodophenyl)-3-methyl-1,3,4-oxadiazol-2 (3H)-one

HRID 1672847Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1672847
[I:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11](=[O:13])[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:14](=O)([O-])[O-].[K+].[K+].CI.O>CN(C=O)C>[I:1][C:2]1[CH:3]=[C:4]([C:8]2[O:12][C:11](=[O:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 21071758HCID 21071758, Verbindung

Produkt 1

HCID 673486545-(3-iodophenyl)-3-methyl-1,3,4-oxadiazol-2 (3H)-oneAusbeute 90,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

5-(3-Iodophenyl)-1,3,4-oxadiazol-2(3H)-one (778 mg, 2.70 mmol) obtained in Step 1 was dissolved in DMF (14 mL), and the mixture was stirred at room temperature for 1 hour after adding potassium carbonate (840 mg, 4.05 mmol) and methyl iodide (0.20 mL, 3.24 mmol). The mixture was stirred after adding water, and the precipitated solid was filtered off and dried to give 5-(3-iodophenyl)-3-methyl-1,3,4-oxadiazol-2 (3H)-one (736 mg, 90%).

Aufarbeitung

  1. stirringThe mixture was stirred
  2. filtrationthe precipitated solid was filtered off
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ea7a6f97ad6f4354a0d3e8fbb083e0ae
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07998954B2

Notizen zur Reaktion

Wird geladen…