Tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoate → 4-(Benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoic acid

HRID 1673444

Reaktionsgleichung

Reaktionsgleichung von HRID 1673444
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:22]=[CH:21][C:13]([C:14]([O:16]C(C)(C)C)=[O:15])=[C:12]([NH:23][C:24](=[O:33])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=4[CH3:32])[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1>FC(F)(F)C(O)=O>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:22]=[CH:21][C:13]([C:14]([OH:16])=[O:15])=[C:12]([NH:23][C:24](=[O:33])[C:25]4[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[C:26]=4[CH3:32])[CH:11]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

Komponenten

3

Edukt 1

HCID 67342913Tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoate

Produkt 1

HCID 578794104-(Benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 31 mg of 4-(benzo[1,3]dioxol-5-yl)-2-(2,3-dimethylbenzamido)benzoic acid as white solid.

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure and methanol
  2. additionwas added to the obtained residue
  3. customa solid substance was separated by filtration

Quellen und Nachweise

ORD-Eintrag
ord-9aa7eda3a966471e8efde12db1382b51
Quelldatensatz
uspto-grants-2011_08
Patentnummer
US07999132B2

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